Mirror the in vivo-situation in your in vitro-setting!
- Oxygen measurement in 3D
- Within the microenvironment of organoids and spheroids
- in static cell culture and Organ-on-Chips
The Problem
500
Around 500 drugs have been withdrawn from the market in the last 70 years.
The reason: side effects that were not noticed during development – despite increasingly advanced in vitro tests.
€ 500 – 1.000 bn.
With development costs of € 1-2 bn per drug, this means a loss of at least € 500 bn. Not to mention the lost opportunities.
But what is the reason for this?
The oxygen concentration in humans (physioxia)
differs significantly from the current conditions in vitro. Experiments are usually carried out under standard conditions which corresponds to approx. 19 % oxygen.
The tissue-specific concentration is often even significantly lower. This means that results from these experiments cannot be directly transferred to humans.
Until now, however, there have been no available measurement methods to reliably determine oxygen in the microenvironment of 3D cell cultures. CAVIGEN offers a solution for this.
Our Solution
Microthermoforming
We use microthermoforming to generate our sensor arrays from oxygen-sensitive films – an arrangement of up to 634 microcavities per square centimeter. Spheroids and organoids can be generated and cultivated in the sensor arrays.
Sensor arrays
Spheroids and organoids can be generated directly in the microcavities from a single-cell suspension. The sensor arrays enable the measurement of oxygen in the microenvironment of the cells and also the characterization of oxygen gradients above the cells.
Our technology enables a new kind of oxygen measurement in cell cultures: analyte consumption-free, in real time and in 3D.
Products & Services
Our products are based on the oxygen measurement in our sensor arrays. Thanks to the microthermoforming process, we are very flexible and can cover a wide range of applications. This ranges from simple cell culture inserts and microtiter plates to complex fluidic systems. In addition to microcavities with different diameters, we are also able to produce oxygen-sensitive microchannels.
For Pharma & CROs
Microtiterplates and assays for substance screening and analysis of OCR in high-throughput experiments.
For (basic) research
Customer-specific geometries of the microcavities in slide-formats and microtiterplates.
For MPS / OoC
Integration of 3D-oxygen measurement in existing microphysiological systems (MPS) or Organ-on-Chip (OoC) devices as a developmental service.
Founder
Christoph Grün
Co-Founder, CEO
Eric Gottwald
Co-Founder, CSO
Cordula Nies
Co-Founder, Customer Development
Discover a new dimension in oxygen measurement!
Are you interested in oxygen measurement in 3D? Do you need a customized solution for your organoids? Or would you like to integrate oxygen measurement into your fluidic systems? We have the answer.